LCI KNOWLEDGE & RESOURCES
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Explore LCI publications, technical guidance, and other resources developed to help scientists and organizations understand complex issues, evaluate evidence, and make informed decisions.
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7 resources2026 · LCI TECHNICAL NOTE · INTERLABORATORY STUDIES
How Many Laboratories Are Enough?
Navigating Laboratory Participation in Interlaboratory Precision Studies
Laboratory Compliance International
A practical framework for evaluating laboratory participation in interlaboratory precision studies based on study purpose, population, design, and required reliability.
2026 · PEER-REVIEWED PUBLICATION · TOXICOLOGY
Key Challenges for In Vitro Testing of Oral Tobacco and Nicotine Products for Regulatory Applications
Emma Bishop, Katarina Aleksa, Damien Breheny, et al.
Alternatives to Laboratory Animals
Recommendations addressing key challenges in the use of in vitro toxicity and disease models for regulatory applications involving oral tobacco and nicotine products.
2026 · PEER-REVIEWED PUBLICATION · TOXICOLOGY
Critical Appraisal of Animal Studies Assessing Risk of Heated Tobacco Products
Xingyu Liu, Rana Tayyarah, and Shaofeng Liu
Archives of Toxicology
A systematic review critically evaluating animal studies used to assess the potential risks of heated tobacco products.
Publication history
An earlier version of this article was published by Nicotine and Tobacco Research and subsequently retracted by the journal for reasons related to an author's institutional affiliation. The work was subsequently submitted to and published by Archives of Toxicology.
View retraction notice ↗2026 · PEER-REVIEWED PUBLICATION · ANALYTICAL SCIENCE
Systematic Investigation of Analyte Protectants to Overcome Matrix Effects for Gas Chromatographic Analysis
Yaqiong Qin, Xiaoyu Wang, Lining Pan, Rana Tayyarah, et al.
Talanta
Investigation of analyte protectants for reducing matrix effects in GC analysis of tobacco alkaloids and primary aromatic amines across diverse matrices.
2025 · COLLABORATIVE STUDY · ANALYTICAL SCIENCE
Determination of NOx in Mainstream Cigarette Smoke
Rana Tayyarah, Leona Sirkisoon, Michael Morton, Aidan Walker, and Thomas Schmidt
Contributions to Tobacco & Nicotine Research
CORESTA collaborative study supporting the development and evaluation of a recommended method for determination of NOx in mainstream cigarette smoke.
2025 · COLLABORATIVE STUDY · ANALYTICAL SCIENCE
Determination of Hydrogen Cyanide in Mainstream Cigarette Smoke
Xingyu Liu, Lisha Chen, and Rana Tayyarah
Contributions to Tobacco & Nicotine Research
CORESTA collaborative study supporting a recommended method for determination of hydrogen cyanide in mainstream cigarette smoke.
2024 · INTERLABORATORY STUDY · PRODUCT CHARACTERIZATION
Comparison of Select Analytes from Different Laboratories in Tobacco and Smoke for Commercial Cigars Across a Range of Designs
Rana Tayyarah, Leona Sirkisoon, and Lee Gentry
Contributions to Tobacco & Nicotine Research
Interlaboratory comparison examining selected tobacco and smoke analytes across commercial cigar designs.

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